Limb-girdle muscular dystrophy includes a group of inherited disorders that cause muscle weakness and decreased amount of skeletal muscle involving the muscles around the hips and shoulders. This causes unusual walking gait, difficulty running, and usually eventual loss of the ability to walk. Onset of the disorder, progression rate and distribution of weakness are variable among the different subtypes of this disorder. Most individuals affected with limb-girdle muscular dystrophy type 2A (LGMD2A) start showing signs of muscle weakness in childhood and are wheelchair bound in 11-28 years after onset. Affected people may experience protruding of the shoulder blade, joint stiffness, and overgrowth of the calf muscles. Intellect is generally not affected. There is no cure for LGMD2A; however medical surveillance and care may help to improve some symptoms and overall condition of life. LGMD2A is caused by pathogenic variants in the CAPN3 gene.