Fanconi anemia (FA) is a clinically and genetically complex disorder. Typical clinical features include bone marrow failure, increased risk for cancer, physical abnormalities, and intellectual disability. Progressive bone marrow failure is responsible for the most significant morbidity and mortality. FA individuals are also at increased risk for multiple malignancies, including acute myelogenous leukemia, myelodysplasia, and solid tumors of the neck, head, oral cavities, and gynecological system. Approximately 70% of FA patients are born with abnormalities, which include abnormal dark or light skin spots, short stature, radial ray defects, abnormally small eyes, malformations of the kidney, genitalia, heart, gastrointestinal tract, ears, and feet. Currently there is no cure for FA, but medical surveillance and care may help to improve some symptoms and overall condition of life. Fanconi anemia is caused by pathogenic variants in 14 different genes. Fanconi anemia type C is caused by pathogenic variants in the FANCC gene.