Herlitz Junctional Epidermolysis Bullosa (H-JEB) is an inherited disorder that causes defects in how the layers of skin are held together. As a result, severe blistering and erosion can occur to the skin even in response to minor injury or friction, such as rubbing or scratching. Individuals affected by H-JEB have blistering over large regions of the body beginning at birth. The blistering can also occur in the moist lining of the mouth and digestive tract, which can make it difficult to eat and digest food. Because the skin chafes and wears away easily, the person is prone to infection. Infants with this condition usually do not survive beyond the first year of life. For those who do survive, infections, hair loss, weak and brittle bones, malnutrition, slow growth, skin cancer, and other complications often occur. There is no cure for H-JEB, however medical surveillance and care may help to improve some symptoms and overall condition of life for those who survive infancy. H-JEB is cause by pathogenic variants in any one of the three genes: alpha-3 (LAMA3), beta-3 (LAMB3), and gamma-2 (LAMC2).