Sjogren-Larsson Syndrome (SLS) is an inherited disorder caused by a defective enzyme called fatty aldehyde dehydrogenase. The most common symptoms of SLS are ichthyosis, which is thickened fish-like skin, muscle tightness in the legs, and intellectual disability. Ichthyosis often becomes progressively worse and is accompanied by itchiness of the skin). Infants with SLS are typically born prematurely. About half of individuals with SLS are never able to walk due to the abnormal muscle stiffness in their legs, and about 40% will have seizures. Intellectual disability varies from mild to severe, although rare individuals with normal intellect have been reported. The normal eye functions are also commonly impaired, but do not typically lead to complete vision loss. People with SLS usually survive until adulthood but require life-long care. No progression of the neurologic findings or intellectual disability occurs after puberty. Those with early symptoms tend to be more severely affected. Sjogren-Larsson Syndrome is caused by pathogenic variants in ALDH3A2 gene.