Limb-girdle muscular dystrophy includes a group of inherited disorders that cause muscle weakness and decreased amount of skeletal muscle involving the muscles around the hips and shoulders. This causes unusual walking gait, difficulty running, and usually eventual loss of the ability to walk. Onset of the disorder, progression rate and distribution of weakness are variable among the different subtypes of this disorder. Most individuals affected with limb-girdle muscular dystrophy type 2D (LGMD2D) start showing signs of muscle weakness in early childhood and are wheelchair bound in about 15 years after onset. Others have milder disease with onset in adolescence or adulthood. This disorder may cause weakening of heart muscles in some people. They may also develop joint and spine deformities. Intellect is generally not affected. Life span may be affected by severity of muscle weakness; as muscles deteriorate, respiratory function may decrease leading to early death as a result of respiratory failure. There is no cure for LGMD2D; however medical surveillance and care may help to improve some symptoms and overall condition of life. LGMD2D is caused by pathogenic variants in the SGCA gene.