Arthrogryposis, mental retardation and seizures (AMRS) is a rare inherited disorder. Arthrogryposis is a condition where the baby is born with multiple joint contractures in their arms and/or legs that cause them to be bent in a certain direction. Infants with AMRS may also have limb malformations, weak muscle tone and a small head. Affected children typically have intellectual disability and some autistic features as well as seizures. There is no cure for AMRS but medical surveillance and care may improve some symptoms and overall condition of life. AMRS is caused by pathogenic variants in the SLC35A3 gene.