Bloom syndrome is an inherited disorder characterized by short stature, skin changes due to sun exposure, and increased risk of cancer. Other health problems may include gastroesophageal reflux, infections, chronic lung disease, diabetes, and infertility. Some individuals with Bloom syndrome have learning disabilities. People with Bloom syndrome remain much shorter and thinner than their other family members. They are also at higher risk than the general population to develop any of the cancers in the general population and are also at risk of being diagnosed with more than one cancer. Life expectancy varies depending on medical complications, but is often into adulthood. The most common cause of death is cancer. Bloom syndrome is caused by pathogenic variants in the BLM gene.